Rigor or Mortis: Best Practices for Preclinical Research in Neuroscience

نویسندگان

  • Oswald Steward
  • Rita Balice-Gordon
چکیده

Numerous recent reports document a lack of reproducibility of preclinical studies, raising concerns about potential lack of rigor. Examples of lack of rigor have been extensively documented and proposals for practices to improve rigor are appearing. Here, we discuss some of the details and implications of previously proposed best practices and consider some new ones, focusing on preclinical studies relevant to human neurological and psychiatric disorders.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Influence of Temperature on Development of Rigor Mortis in Dog Hearts.

• The effects of temperature on the development of rigor mortis in cardiac muscle have never been investigated systematically. Brecher and Kissen found that pressure-volume characteristics of non-beating, submerged dog ventricles remained constant for at least 30 minutes following circulatory arrest at 35°C. Using similar methods, Griggs et al. found this period to be approximately 80 minutes a...

متن کامل

Assessment of Mechanical Properties of Muscles from Multi-Parametric Magnetic Resonance Imaging

We hypothesized that a relationship existed between the mechanical properties and the magnetic resonance imaging (MRI) parameters of muscles, as already demonstrated in cartilaginous tissues. The aim was to develop an indirect evaluation tool of the mechanical properties of degenerated muscles. Leg and arm muscles of adult rabbits were dissected, and tested 12 hours post mortem, in a state of r...

متن کامل

From the Editors Grand Challenges and Inductive Methods: Rigor without Rigor Mortis

Editor’s note: This editorial is part of a series written by editors and co-authored with a senior executive, thought leader, or scholar to explore new content areas and grand challenges with the goal of expanding the scope, interestingness, and relevance of the work presented in the Academy of Management Journal. The principle is to use the editorial notes as “stage setters” to open up fresh, ...

متن کامل

Traceability of rigor mortis of muscle using a texture analyzer: a feasibility study

Rigor mortis is one of the most important changes of muscle at earlier time postmortem, which ultimately affects meat palatability. However, there seems no efficient way to track the whole process of rigor mortis continuously and automatically. This study is designed to explore a new method to realize the traceability of the onset and development of rigor mortis of muscles using a texture analy...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Neuron

دوره 84  شماره 

صفحات  -

تاریخ انتشار 2014